Crystal Structure of Staphylococcus Aureus Autolysin E, Method of Producing the Crystal and Its Use in Screening Methods

Publication Number: WO2016173603A1
Application Date: 27. 4. 2015
Assignee/Applicant: Jožef Stefan Institute [SI]
Inventor: Marko Mihelič, Miha Renko, Dušan Turk
Title: Crystal Structure of Staphylococcus Aureus Autolysin E, Method of Producing the Crystal and Its Use in Screening Methods
Description: The invention concerns the determination and evaluation of the crystal structure of autolysin E (AtlE) of Staphylococcus aureus (S. aureus), or a crystallizable fragment of AtlE, a method for producing a crystal of AtlE and the respective crystallization kit, and its use in a method for screen- ing an inhibitor of the N-acetylglucosaminidase activity of AtlE, for obtain- ing atomic spatial relationship data, and for identifying a binding com- pound of AtlE, e.g. by in silico screening.
Drawings:
Category: Biological Sciences
Technology application codes: Biological sciences, Measurements and standards
Market application codes: Genetic engineering / molecular biology
www: https://worldwide.espacenet.com/patent/search/family/053180702/publication/WO2016173603A1?q=WO2016173603A1
Patent offices: WIPO

 

Extended patent application

Publication Number: CA2982386C
Application Date: 27. 4. 2015
Assignee/Applicant: Jožef Stefan Institute [SI]
Inventor: Marko Mihelič, Miha Renko, Dušan Turk
Title: Crystal Structure of Staphylococcus Aureus Autolysin E, Method of Pro-ducing the Crystal and Its Use in Screening Methods
www: https://worldwide.espacenet.com/patent/search/family/053180702/publication/CA2982386C?q=WO2016173603A1

 

Extended patent application

Publication Number: EP3289078B1
Application Date: 27. 4. 2015
Assignee/Applicant: Jožef Stefan Institute [SI]
Inventor: Marko Mihelič, Miha Renko, Dušan Turk
Title: Crystal Structure of Staphylococcus Aureus Autolysin E, Method of Producing the Crystal and Its Use in Screening Methods
www: https://worldwide.espacenet.com/patent/search/family/053180702/publication/EP3289078B1?q=WO2016173603A1

 

Extended patent application

Publication Number: US10428320B2
Application Date: 27. 4. 2015
Assignee/Applicant: Jožef Stefan Institute [SI]
Inventor: Marko Mihelič, Miha Renko, Dušan Turk
Title: Crystal Structure of Staphylococcus Aureus Autolysin E, Method of Producing the Crystal and Its Use in Screening Methods
www: https://worldwide.espacenet.com/patent/search/family/053180702/publication/US10428320B2?q=US10428320B2