Method for Immobilization of Heparin on a Polymeric Material

Publication Number: EP2997984B1
Application Date: 17. 9. 2015
Assignee/Applicant: Jožef Stefan Institute [SI], University of Maribor [SI]
Inventor: Metod Kolar, Alenka Vesel, Martina Modic, Ita Junkar, Karin Stana – Kleinschek, Miran Mozetič
Title: Method for Immobilization of Heparin on a Polymeric Material
Description: The present invention refers to a method for immobilization of heparin on polymeric material, said method comprising selecting a substrate made from a polymeric material, pre-treating said substrate, mounting said substrate into a vacuum chamber, evacuating the vacuum chamber to pressure essentially below 100 Pa, preferably below 1 Pa, selecting a source of NH2 radicals, leaking the NH2 radicals from said source into said vacuum chamber during continuous pumping of said vacuum chamber, interacting said NH2 (NH2) radicals with said substrate made from a polymeric material, evacuating said vacuum chamber, venting said vacuum chamber to atmospheric pressure, and covalent bonding of activated heparin on said substrate.
Drawings:
Category: Nanotechnology and New Materials
Technology application codes: Physical and exact sciences, Measurements and standards
Market application codes: Medical / health related, Industrial products
www: https://worldwide.espacenet.com/patent/search/family/051869176/publication/EP2997984B1?q=EP2997984
Patent offices: EPO